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Addison's Disease

Addison’s Disease – General Information

Addison’s Disease is rare and chronic endocrine disorder, and is also called chronic adrenal insufficiency, hypocorticism and hypocorticolism. This type of disorder can appear in children but also in adults, and can occur because of a large number of causes. This type of disease results when the body produces insufficient amounts of some types of hormones produced by the adrenal glands. The adrenal glands are located above of each of the two kidneys. These types of glands take part of the body’s endocrine system, and can produce hormones that give certain information to almost every organ and tissue in the person’s body. In Addison’s Disease, the adrenal glands usually produce a low level of cortisol, which is considered one of the hormones classified in a group called the glucocorticoids. In some cases, this type of disease also produces an insufficient dose of aldosterone, classified also in a group called mineralocorticoid hormones. This type of endocrinal disorder can be even life threatening. Also known as adrenal insufficiency or hypocortisolism, Addison's Disease can appear at any age, but is most encountered in people with ages between 30 and 50. The treatment for this kind of disease includes administrating hormones to replace the insufficient doses being made by the adrenal glands. This disease is usually diagnosed by blood tests or medical imaging and even additional investigations. The replacement hormones are administered orally, and include hydrocortisone and fludrocortisone . If the disorder occurs by an unknown problem, this is addressed. It is necessary to monitor the disease.

Addison’s Disease – Symptoms

Addison’s Disease is not apparent in most of the cases until more than 90% of the adrenal tissue has been destroyed, and the adrenal capacity is low, also the hormones production. It can take months, even years and is also known as primary adrenal insufficiency. Once the disease has reached a chronic stage, the are some first symptoms that include severe fatigue and weakness, loss of weight, increased pigmentation of the skin, nausea, vomiting, faintness, salt cravings, painful muscle and joints, and low blood pressure. Due to the fact that these symptoms have a slow progression and have a non specific cause, they are ignored by some doctors, and even missed, and this can lead to aggravation of some illnesses, like a minor infection that leads to an abnormally long convalescence which triggers any investigation. In most of the cases, the attention of the medical assistants is weakening, in the Addison’s Disease case, when a Addisonian crisis take place, caused by the adrenal glands. If the Addison’s Disease is not previously diagnosed, it can lead to a process that suddenly affects the adrenal function, causing adrenal hemorrhage, or an infection or trauma. This situation can also develop in those with long term oral glucocorticoids that have suddenly stopped taking the medication prescribed. The glucocorticoids insufficiency can also lead to the appearing of a myxedema coma, and the thyroxine that is given in combination with glucocorticoids can lead to a crisis.
If you encounter any of the symptoms above, seek medical attention as soon as possible.

Addison’s Disease – Treatment

The main treatment in the curing process of the Addison’s Disease is the replacement of the missing aldosterone, and in some cases, providing therapy for replacement of cortisol. If the patient suffers a surgery or becomes pregnant, caution is the first measure taken. Due to the lack of corisol and aldosterone, which cause Addison’s Disease, the first stage of the treatment is to replace them with similar steroids. Cortisol is in most of the cases replaced, by an oral way, by cortisone acetate or hydrocortisone tablets taken in doses, ones in the morning and ones in the afternoon doses. Aldosterone is replaced by an aldosterone synthetic steroid called fludrocortisone or Florinef tablets given once a day. These prescriptions are given depending on each patient, on their any existing medical conditions. As an urgent measure, if the patient suffers a surgery, hydrocortisone is administrated IV (intravenously).

Patients suffering with Addison's Disease should consider a way to treat minor illnesses using extra salt and fluids. This type of measure is taken if the patient’s symptoms include fever, vomiting or diarrhea. The persistence of these signs, leads to an immediate treatment including the process taken in an emergency room, where the doctor injects intravenous saline, salt water, and hydrocortisone. Since this type of disease is considered to be a chronic condition, every day replacement medication can never be stopped. If the crisis is installed, also known as Addisonian crisis, the treatment includes the injection of a steroid preparation through a needle IV (intravenously). Dehydration and salt loss symptoms will also receive the treatment by administering, with all safe measures taken, balanced solutions through the intravenously way. If the pressure of the patient’s blood goes down to a dangerous low level, medications are safely administered to elevate it until the steroids can be effective. If a patient suffers of the Addison’s Disease, he have to take, for the rest of his life, a prescribed steroid preparation, or hydrocortisone, and a replacement for aldosterone, called fludrocortisone, administered orally. If one of the patients encounters symptoms like Nausea and Vomiting, when they cannot hold down their medications, he or she will have to seek for medical attention to get, by intravenously way, the medications needed. Also, when suffers an injury or has any kind of infection, the normal dose of the replacement steroid will need to be doubled.

The symptoms like low blood pressure, low level of blood sugar, and high levels of potassium, during an Addisonian crisis, can threaten the life of the patient.  The standard therapy of treating Addison’s Disease includes injection of hydrocortisone, or salt water (saline), and sugar (dextrose). The treatment applied is in most of the cases effective. The dose of hydrocortisone is decreased when the patient takes fluids and the medications prescribed, by mouth, and stops when an amount of steroid is achieved. Maintenance therapy can include doses of fludrocortisone acetate taken by mouth if the level of aldosterone is low.  The treatment medication for this disorder that is taken by the mother is usually considered safe for baby during a pregnancy.



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20 Addisons Disease Medication Reviews

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2 star: 0.00%  (0)
1 star: 0.00%  (0)

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151 of 263 people found this review helpful:
5.0 out of 5 stars FLORINEF
   By (TX, United States)
  Customer since 9/22/2008 - (2 orders)
  Ordered from
  Ordered Florinef

My father had missing a kidney and both Superarenal glands due cancer
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111 of 194 people found this review helpful:
5.0 out of 5 stars A 50% saving, 7 weeks earlier than expected
   By (Ecuador, Ecuador)
  Customer since 1/10/2009 - (4 orders)
  Ordered from
  Ordered Florinef

My mother needed fludrocortisone which she could only find for USD125 here in Ecuador. When I found it at PharmacyEscrow.com for half that price including shipment, I thought there had to be a catch like the order couldn't be delivered to my country, the prescription was not acceptable, or there were hidden charges.

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I did not select express shipment or priority processing, so I expected to receive the order in two months, and with extra charges from customs or hidden fees.

But two weeks later, the mailman came with a package from Fiji Islands. I opened the package expecting some south-pacific fruit. But there it was my mom's fludrocortisone! I couldn't believe it: when I ordered from other stores on relatively nearby countries like the US it took 4 times longer. Best of all there were no custom or extra charges: nil, zero nada.

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116 of 217 people found this review helpful:
5.0 out of 5 stars delivery and quality
   By (gozo, Malta)
  Customer since 5/29/2008 - (3 orders)
  Ordered from
  Ordered Florinef

they arrived on time as i was told and they are the genuine meds i need to keep my breast cancer under control

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73 of 133 people found this review helpful:
5.0 out of 5 stars Fast and professional supplier. Well organised.
   By (leicestershire, United Kingdom)
  Customer since 11/3/2007 - (15 orders)
  Ordered from
  Ordered Florinef

The personal service is second to none in that the online live chat feels like you are in your local chemist. All drugs are exactly as described and the same as the ones supplied to me locally in my home country. The user selectable email drug reminder system is a great idea and always ensures you don't run out. The speed of delivery to the UK is 8-10 days which is very quick indeed. On one occasion a UK courier failed to deliver the package to us and returned it to this supplier, I rang PharmacyEscrow.com and they re shipped no charge very quickly. Free delivery for life saves a fortune so I subscribed for that straight away.
Definitely a company to count on being so well set up and focused on customer service.
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30 of 59 people found this review helpful:
5.0 out of 5 stars Thanks to PharmacyEscrow, I can sleep again!
   By (SC, United States)
  Customer since 9/16/2009 - (2 orders)
  Ordered from
  Ordered Florinef

As an Adrenal Fatigue sufferer on hydrocortisone, I needed Florinef to help my body retain sodium. No matter how much sea salt I supplemented, I could not get my lab numbers up and I could no longer sleep through the night due to frequent urination. My doctor wouldn't prescribe Florinef for me because he feared it would raise my blood pressure - so I was left to fend for myself.
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