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Anemia Associated with Chronic Renal FailureAnemia Associated with Chronic Renal Failure General InformationAll patients with renal failure are prone to many complications. Anemia is not really a diseases, is rather a reflection of some other disorders inside an organism. Any form of anemia results from the imbalance between the production of blood and normal rates of blood loss. The progressive deterioration of renal function is a long standing disease called chronic renal failure and among other side effects (complications) we can precise Anemia Associated with Chronic Renal Failure. This condition can not be avoided when suffering of CRF (chronic renal failure) because during this disease the production of erythropoietin. The susceptibility to infections of any kind and very easy bruising are caused by abnormalities of the platelet functions and of the white blood cells. Anemia Associated with Chronic Renal Failure is usually a very common complication in the advanced form of this disease being present almost all the time. This condition is caused when the production of red cells of the blood inside the bone marrow is reduced. We can also say that anemia can be characterized by a minimized capacity of the blood that is carried through the blood. In scientific words, this means a low hematocrit (the volume of blood composed of erythrocytes or red blood cells) and a low concentration of hemoglobin. A normal healthy person has the hematocrit of about 35% and 15 grams per deciliter of hemoglobin. In Anemia Associated with Chronic Renal Failure, the red cells of the blood have a lower rate of survival because of the uremic toxin. Anemia Associated with Chronic Renal Failure SymptomsRenal failure, in its early stages, is usually asymptomatic and only the signs produced by the underlying conditions may alert the individual to go to medical care. Anemia Associated with Chronic Renal Failure has an important contribution to the symptoms that preclude cure and reduce the quality of living in an ill individual. This kind of anemia is primarily resulting from the impossibility of the part of the kidney that is impaired to produce the necessary quantity of erythropoietin. The red cells of the blood have an important role inside one’s organism because they help carrying the oxygen to different parts of the body. This may do real harm to the patients who is undergoing a treatment for the disease because he may not have benefit at the maximum from the treatment and the organism may not have the same resistance to fight against the disease. You may feel you do not benefit anymore from the energy you had before. The feelings of intense tiredness, weakness and problems with the daily concentration may be signs you suffer from Anemia Associated with Chronic Renal Failure in the case you have anterior problems with the urinary tract. Any form of anemia leads to the symptoms listed above, along with headache, shortness of breath, dizziness, and paleness, loss of body weight and fast beats of the heart. All these symptoms stay in your way because they interfere in your daily work. This could also affect your psychological side because these feelings become permanent and may lead you to frustration and feeling hopeless. Anemia Associated with Chronic Renal Failure TreatmentIn a normal healthy body, the erythropoietin is produced entirely in the kidneys. But when these major organs are affected by a disease, the cells that form this hormone are damaged, and Anemia Associated with Chronic Renal Failure usually occurs soon after the installation of the illness. Because the main cause of Anemia Associated with Chronic Renal Failure is the loss of erythropoietin, the hormone preventing the low number count of the blood (anemia) that plays an important role in stimulating the bone marrow to produce red cells of the blood, the aim of any treatment against this type of anemia is to use rHuEPO (recombinant human erythropoietin). Epoietin alpha or EPOGEN, a glycoprotein resulted from the recombinant DNA process can correct Anemia Associated with Chronic Renal Failure and usually people who suffer of these kind of dysfunctions benefit of this treatment. When using this therapy, the need of transfusion is significantly low but the efficiency is really encouraging. Before a doctor starts this treatment with a patient, the hematocrit should be targeted and the levels of iron evaluated properly and entirely. If these two are not done, the response to erythropoietin treatment may be blunt if the stores of iron are low. Hiperviscosity effects can appear if the therapy is not started gradually in order to avoid that the mass of red blood cells increase in excess. A proper therapeutic regimen consists in injections done either directly into a vein (intravenously), during dialysis or under the skin (subcutaneous). This is done even by the patient himself or by a nurse. The needed dosage is 100-130 U/kg that is divided into maximum three smaller doses. Usually, injections with erythropoietin are given as long as the patient is on dialysis and has the aim to keep the hematocrit (the count of the red cells of the blood) at a stable number, somewhere between 25-40%. In the case of a kidney transplant, there is no need of these injections because the new kidney will produce itself the quantity needed. Anemia Associated with Chronic Renal Failure must not be treated with transfusions in order to avoid that the fluid overloads in cases of cardiac patients and infections although this method was used for many years before the injectable form of erythropoietin was synthesized and thus, discovered and is very similar to what a healthy kidney produces. So, treatments for Anemia Associated with Chronic Renal Failure had known significantly changes during the past years. Along with the transfusions of red blood cells, doctors administrated to patients a hormone, testosterone. The effect of the last one was very minimal and ended to be correlated with virilizing adverse effects. Before proceeding with any therapy, the rest of deficiencies must be assessed, for example intoxication with aluminum, folate deficiency, or vitamin B12 deficiency. It is highly important to check systematically the iron stores during therapy because not always a fast proliferative response comes along the proper availability of iron. If the levels of iron are not yet normal, he therapy followed should be immediately changed. |
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