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Chronic Myelogenous LeukemiaChronic Myelogenous Leukemia – General InformationChronic Myelogenous Leukemia is considered a rare form of cancer which affects the patient’s blood cells. It is called chronic leukemia due to the fact that it generally evolves even more slowly than the acute leukemia. In some cases it lasts for more than two to three years. The worse part about this type of cancer is that does not appear as a solid tumor, which can be effectively removed by surgical procedures. Luckily, some of the newest medications are able to help the patients to improve their leukemia medical condition. Stem cells transplant is considered the most effective treatment option, which can lead to the curing of the disease. This type of therapy can be applied in combination with chemotherapy in order to achieve a long term effect. Patients can live for some years if the cancer is put in remission. However, this fact can not be emotionally supported by the most of the patients. The cause of the disease is still unclear, but medical scientists study the evolution of the Chronic Myelogenous Leukemia. This type of cancer appears from a complex process of mutations which develops from chromosomes and genes in the patient’s blood cells. Due to this fact the cancer can not be surgically removed. Chronic Myelogenous Leukemia can lead to the appearance of many complications depending on the cancer stage, and can appear before the leukemia is diagnosed or, in some cases, as severe side effects of the available treatment. The main risk factor of developing this type of cancer is the exposure to very high levels of radiation.Chronic Myelogenous Leukemia – SymptomsThe signs and symptoms of the Chronic Myelogenous Leukemia can vary depending on the phase of the leukemia that the patient suffers from. In the early stage of the disease, it does not produce any signs and symptoms. Even when the patient experiences some abnormal symptoms, he or she declares them vague. The most common symptoms include fever, losing weight without any exercise, loss of appetite, feeling ran down or tired, pain or fullness in the inferior part of the ribs, on the left side or sweating excessively during sleep, known as night sweats. There are other many signs and symptoms that can develop in the advanced stages of the disease, or when the Chronic Myelogenous Leukemia is left untreated. In these cases, the patient can experience symptoms such as anemia, enlarging of the spleen, shortness of breath, fatigue, pale skin, repeated infections, easy bleeding, easy bruising, pinprick sized red marks on the skin, called petechiae, stroke, bone pain or joint pain. As we have already said, it is very hard to prevent the appearance of this kind of cancer due to the fact the main risk factor is the exposure to abnormally high levels of radiations. If the patient manages to prevent the exposure, he can also prevent the cancer’s development. Other methods of preventing the disease are not effective enough. A person can live with the cancer without knowing about its presence, and it is usually discovered accidentally in a routine blood test. Most of the patients experiencing early symptoms, including fatigue, ignore them, supposing that they are caused by work.Chronic Myelogenous Leukemia – TreatmentMost of the patients suffering from Chronic Myelogenous Leukemia get their prescriptions and advices from their hematologist, a doctor specialized in blood diseases. There are also patients that work with an oncologist, a doctor specialized in cancers. It is very hard to prescribe a specific treatment for each patient because there are many options, but also because every day, new therapies appear. This gives hope to most patients, especially when they prove its long term effectiveness. The main goal in this kind of disease’s treatment is to destroy the affected blood cells that have become contaminated with the gene. In most of the cases, the treatment applied doesn’t cure the patient’s disease, but they can get a long term remission. There is a large variety of effective drugs that are available in the treatment of Chronic Myelogenous Leukemia. The main goal of the medicines is to stop the abnormal gene from affecting the cells. Most doctors apply several drugs (the most effective ones), which can include imatinib prescribed as Gleevec, dasatinib prescribed as Sprycel, and nilotinib prescribed as Tasigna. However, these types of drugs are administered in tablet form and are considered very powerful cancer drugs that can provoke severe and life threatening side effects. The main treatment options for treating Chronic Myelogenous Leukemia can include stem cell transplant, chemotherapy, biological therapy and many other medical trials. The stem cell transplant, also known as bone marrow transplant, is considered a potential cure for this type of leukemia. But, as effective it can be, the stem cell transplant is also considered a risky operation which can cause severe complications, some of them, even life-threatening. Bone marrow transplant is used by the most of the doctors because the other treatment options are, in most of the cases, inefficient. Nowadays, the stem cell transplant is generally applied only after the disease has resisted to the all other treatment options or if it has continued to evolve. But, due to the fact that the bone marrow transplant can achieve a cure or, in some cases, a long term remission of the leukemia, the patient has to make another challenging decision choosing between immediate transplant or other treatment option. But, there are cases in which the patient can decide to have his own bone marrow collected and then stored for future harvesting. This type of operation is usually known as bone marrow harvest or the stem cell collection. The operation, in most the cases, is usually recommended for patients who do not find a perfect donor for their bone marrow transplant. Patients suffering from Chronic Myelogenous Leukemia can choose chemotherapy as treatment for their disease. This therapy consists in tablets that are taken in orally, and it is supposed to destroy the excess white blood cells. It is also used as preparation for the bone marrow transplant. Biological therapy consists in an injection, with a medication called Interferon alpha, and was considered the common treatment for Chronic Myelogenous Leukemia. This kind of procedure is also applied when the female patient is pregnant or when all the other options have failed. But, the Interferon can cause severe side effects which can worsen the patient’s medical health condition. |
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