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Clornorchis Sinensis (Liver Fluke)

Clornorchis Sinensis (Liver Fluke) – General Information

Clornorchis Sinensis (Liver Fluke) is a type of fluke included in the Trematoda class. It is generated by a parasite which is firstly developed inside the body of a snail. This parasite, named phylum platyhelminthes, grows in fresh-water until a snail eats it. In the interior of the snail body, the parasite turns into an adult, continues to grow and it then multiplies.  After it reaches its final stage of evolution which is called the redia, the parasite is eliminated in a fresh-water environment again. From this point, it will search for a new host, a fish; inside the fish’s body, more exactly in the fish’s muscles, the parasite creates a cyst around it. Then the parasite encapsulates itself in this cyst, for protecting. This is a useful method even when people eat the fish muscle. The cyst protects the parasite against the acids in the human gastric system and this way it reaches the intestines. From the intestines, the parasite navigates to the liver and it establishes there. Once it settles its habitat in the liver, it feeds with the bile which is created by the liver. This way it can produce more than 10 eggs per hour which assure a fast and threatening evolution.

Clornorchis Sinensis (Liver Fluke) is more common in the regions such as China, Southeast Asia, Japan and Taiwan, where it affects more than 32 millions of people each year. If not diagnosed and treated in due time, this disease can lead to serious complications and even death.

Clornorchis Sinensis (Liver Fluke) – Symptoms

Clornorchis Sinensis (Liver Fluke) appears once the parasite reached the liver and causes an epithelial hyperplasia, an inflammatory reaction and, in some cases, even an adenocarcinoma of the ducts situated in this area. In the most severe cases of Clornorchis Sinensis (Liver Fluke), the parasite consumes all the quantity of bile which is produced by the liver; this will lead to the impossibility of the human body to digest foods which are rich in fats. On the other hand, the fast multiplication of the parasite and the numerous eggs which it produces can result in an obstruction of the ducts in the liver.  

  The most common signs and symptoms in the case of Clornorchis Sinensis (Liver Fluke) are: anorexia: an eating disorder which usually appears in the case of teenagers. People who suffer from anorexia are obsessed with their weight and they present extreme weight loss. Despite this, they are sure that they are overweight and they try different techniques to loss pounds: usage of laxatives in order to eliminate even the few aliments they have eaten or refusal of any kind of food.

  • Fever: this symptom can appear in the case of a high number of disease and problems. In most of the cases, it does not indicate a serious disorder, but it can also be one of the first signs of a severe interior problem.
  • Diarrhea
  • Chills
  • Hepatomegaly: is the exact symptom which characterizes this disorder, as it is described as the condition of suffering from an enlarged liver.
  • Abdominal pain
  • Epigastric pain
  • Clornorchis Sinensis (Liver Fluke) – Treatment

    If you observe the presence of one or more of the symptoms described above, you should immediately consult a doctor and ask him to perform some tests in order to detect the exact cause of your problems. In the first place, the tests can help a possible sufferer of Clornorchis Sinensis (Liver Fluke) to know the exact diagnosis. The doctor should also take into account the medical history and any other relevant information about the patient’s life: any recent diets, travels or visits to certain regions with a high risk of developing this disease. A physical examination is also recommended and it should include a palpation of the liver in order to detect any pain or feeling of discomfort. The most common tests which are performed in such situations are: examination of a sample of feces in order to detect parasite eggs, an endoscopy, sonoghaphic assessments or radiological assessments. An additional test which should be taken into account is the Elisa blood test; this test, however, could not present sure results, because of the cross-reaction. This kind of reactions appear when a specific agent responds with antibodies which are specific for other disease agent; in such cases, the doctor may observe the presence of a fluke, but he can not identify where the disorder is located.  

    If the patient is diagnosed with Clornorchis Sinensis (Liver Fluke), the doctor will probably choose one of the following ways of treatment: administration of albendazole or administration of praziquantel or in some cases, administration of triclabendazole, bithionol or mebendazole. These drugs are used in order to force the parasites inside the body to drop off from the blood vessels which they use as hosts. Albendazole is administrated in order to suppress the infection and to inhibit the metabolism of the parasites, which will finally lead to the death of the parasites. Praziquantel is administrated in order to treat more severe forms of the disorder; it usually treats a combination of liver fluke, blood fluke, intestinal fluke and lung fluke. The duration of the treatment in the case of Clornorchis Sinensis (Liver Fluke) depends on the severity of the disorder and on the type of parasites which caused it. However, the treatment usually lasts from a couple of days to a few weeks. In the first phase, these drugs can provoke side effects, such as dizziness, headaches or diarrhea, but they disappear as the body gets used with the drugs. The evolution of Clornorchis Sinensis (Liver Fluke) is quite positive after the sufferer starts the treatment. However, in more severe cases, the patient can become vulnerable to other disorders or infections. If the infection is located in the brain, the patient can experience sudden death, because of the destruction of the brain tissue or the entire central nervous system.
     The preventive measures which a person can take in order to protect himself from Clornorchis Sinensis (Liver Fluke) are:

    • The purification and the boiling of the water you drink when you travel
    • If you are in an area where this disorder is quite common, avoid unprepared or undercooked food.



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