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Dientamoeba Fragilis

Dientamoeba Fragilis – General Information

Dientamoeba Fragilis is a single celled parasite which affects the gastrointestinal tract of the individuals. The trophozoites of the parasite generally have two nuclei. The name of this type of parasite refers to the fact the stages of evolution are fragile, as the parasites can not survive for a long period of time in the patient’s stool, after leaving the body of the host. The infection with Dientamoeba Fragilis is also known as Dientamoebiasis. This kind of infection usually develops symptoms such as abdominal pain, diarrhea, weight loss, and fever. The parasite is considered a form of trichomonad, which is a flagellated organism, but this parasite do not present flagella, losing them during the secondary stage of evolution. The scientists could not exactly determine the life cycle of the parasite. It is also challenging to classify the stages of evolution, because the parasite can only be found in the patient’s stool in its trophozoite form. The form of transmission is the fecal - oral way. The Dientamoeba Fragilis parasite is usually confused with another parasite, called Histomonas, which is transmitted through the eggs of the helminth Heterakis. The form of replication of this parasite is binary fusion, and the moves are enabled by pseudopodia. It survives by phagocyting intestinal cells. This kind of infection is usually treated with various medicines that depend on each individual’s medical condition and medical history. The most successful drugs are considered Iodoquinol, Doxycycline, Metronidazole, Paromomycin, which have proved to be effective. To determine the diagnosis of the disease, the doctor can require a stool sample from the patient.

Dientamoeba Fragilis – Symptoms

Dientamoeba Fragilis is a nonflagellate trophozoite parasite, and it is considered to be the smallest parasite that can live in the patient’s large intestine. This kind of parasite can lead to the appearance of small inflammations of the large intestine, accompanied by mucous diarrhea or gastrointestinal dysfunctions. The parasite can also lead to the appearance of other conditions, but, in most of the cases, it causes the Dientamoebiasis infection. The Dientamoeba Fragilis can also infect patients who live in places in which a poor hygiene is maintained. The main form of diagnosing the disease is by taking a stool sample from the patient, which is also necessary to determine the correct dose of treatment. In most of the cases, the Dientamoeba Fragilis infection is asymptomatic, but when signs and symptoms do appear, they include: weight loss, loose stools, intermittent diarrhea, abdominal cramping, and anorexia, loss of appetite, stomach pain and abdominal tenderness. There are cases in which the infection caused by the parasite can affect the surrounding organs. In such cases, the signs and symptoms can include itching of the anal or vaginal area, insomnia, irritability and restlessness, and vague gastrointestinal symptoms (intermittent abdominal pain and nausea). If the patient has mild abdominal pain, accompanied with insomnia and irritability, or experiences severe anal and vaginal itching, he should contact the doctor as soon as possible. The best way to prevent the appearance of the infection is to practice a good hygiene. Keeping the household permanently clean is also recommended.

Dientamoeba Fragilis – Treatment

There are many drugs that are widely recommended by doctors to treat Dientamoeba Fragilis. Such medications are known to have paraciticidal activity. The bad news about is that when the treatment is tested in vitro, it proves to be inaccurate and unreliable. This is due to the fact that the Dientamoeba Fragilis requires a media which contains a bacterium that feeds the parasite, called xenic media. That is why the doctors do not prescribe long term treatment trials. However, there are many agents that can eradicate the parasite from the stool and lead to a great improvement of the symptoms. The most prescribed medicines in the case of sufferers from an infection with Dientamoeba Fragilis are Iodoquinol and Doxycyline drugs. There is a list with available treatments for this disorder which include Iodoquinol, Doxycycline, metronidazole, Paromomycin, and Secnidazole, that have been reported as successful options. To determine the exact treatment for each individual, the doctors need a sample of stool from the patient, for testing. Due to the fact that the parasite is not present in every sample of stool, the patient may need to bring samples for more than one time. Persons infected with Dientamoeba Fragilis can develop other conditions such as pinworms eggs. The treatment options with Iodoquinol, Paromomycin and tetracycline are contraindicated in patients with the age under 8 years, female patients that are pregnant and lactating. For such patients, the recommended option is metronidazole. There are cases in which the doctor can prescribe Flagyl to treat Dientamoeba Fragilis.

To relieve symptoms in young patients, doctors usually recommend a treatment trial with diiodohydroxyquin medicine. Doxycycline is a widely prescribed tetracycline antibiotic which can be used in combination with other drugs to treat this disease and other conditions. For example, this drug is also applied to prevent or reverse the progression of anthrax. The effect of Doxycycline is to slow the growth of the bacteria, and by doing this, the immune system of the patient’s body can destroy it. This medicine is contraindicated if the patient is allergic to any ingredients that are found in the drug or to any other tetracycline medications. Furthermore, if the patient is taking acitrecin, oral contraceptives or penicillins, such as amoxicillin he or she is not allowed to start using Doxycyline. The metronidazole medicine is an oral antiprotozal and antibacterial, which is used to treat certain bacteria, or to prevent any infection from occurring either after or during surgery. It is a drug used to treat many conditions determined by the doctor. The effect of the metronidazole medicine is to enter in the bacterial cell, destroying certain components from it, leading to the destruction of the bacteria. The drug is contraindicated if the patient is allergic to any of its ingredient or other nitroimidazoles, if the patient is pregnant, if the patient is taking busulfan or is drinking alcoholic products on a regular basis. Iodoquinol medicine is an amebicide, which is used to treat certain infections of the intestine. The main effect of the drug is to kill the parasites inside the intestines.




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