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Gastrointestinal Stromal Tumor

Gastrointestinal Stromal Tumor – General Information

Gastrointestinal Stromal Tumor is a type of cancer that affects the patient’s gastrointestinal system, which includes the esophagus, gallbladder, small intestine, liver, colon and rectum. This kind of cancer is considered a rare one which is different from the other types of gastrointestinal cancers, due to the type of tissue where it develops. In the past, scientists thought that the Gastrointestinal Stromal Tumor is a type of nerve or muscle tumor, but nowadays they discovered that it starts in the cells found in the walls of the gastrointestinal tract, called interstitial cells of Cajal. These types of cells transmit information to the gastrointestinal system which helps in the proper movement the food and liquid through the tract. The Gastrointestinal Stromal Tumor is classified as a type of cancer called soft tissue sarcoma. This sarcoma appears in the connective tissues which can include muscle, fat, nerves, blood vessels, bone or cartilage. This kind of tumor can be classified in two forms, benign (non cancerous) and malignant (cancerous). In most cases, it is challenging for the doctors to determine if the tumor is malignant, and this is why they take in consideration many factors such as the size of the tumor, if it is largely spread, the location of the tumor and how many dividing cells are present. There are not many risk factors from which the patient can develop the disease, but doctors say that it can be caused by a mutation on the KIT gene, or, in some particular cases, a mutation on the PDGFRA gene.

Gastrointestinal Stromal Tumor – Symptoms

Patients who suffer from Gastrointestinal Stromal Tumor can experience no signs and symptoms at all, but in most cases, the disease can cause a few reactions. In some cases, the signs and symptoms characteristic for this cancer can be caused by many other common conditions that are not classified as cancerous illnesses. It is very hard to diagnose the Gastrointestinal Stromal Tumor in an early stage due to the lack of signs and symptoms, but when they do appear, they can include pain or discomfort in the abdomen area, nausea or vomiting, vomiting blood or having blood in the stool, fatigue caused by the anemia, low blood counts. In most cases, these symptoms appear as vague reactions. There are cases in which the patient can experience trouble swallowing, gastrointestinal hemorrhage or metastases, especially in the liver. The patient can also develop intestinal obstruction, which is generally rare – this condition is caused by the fact that the tumor has spread too much. After diagnosing the abdominal pain and discomfort, the tumor usually starts to become larger in time. In most cases, the diagnosis is made with the help of a biopsy which can include endoscopicaly, percutaneously and ultrasounds procedures or in the surgical approach. After experiencing one of the symptoms above, it is very important that the patient seeks medical support as soon as possible. Also is very important to treat Gastrointestinal Stromal Tumor in an early stage in order to prevent the appearance of any severe complications such as an increase in the chances of cancer remission. 

Gastrointestinal Stromal Tumor – Treatment

Gastrointestinal Stromal Tumor is usually diagnosed during a routine test for other more common conditions. Generally, the doctor applies several procedures to diagnose the disease which can include upper endoscopy, which is the inspection of organs or cavities using a device called endoscope, laparoscopy, which is an exploration using a device also known as laparoscope, ultrasounds, which uses sound waves to take images of the patient’s internal organs, computed tomography scan, which is a radiographic type of procedure which works by producing a film that represents a detailed cross section of organ structure, and so on. In most cases, these tests help the doctor to know if the patient suffers from Gastrointestinal Stromal Tumor, where the tumor is located, what is the size of the tumor, or if the cancer has spread to the other areas of the gastrointestinal tract. Usually, after the patient has been diagnosed with the disease, the doctors perform a biopsy, a tissue sample, to determine if the tumor is malignant, cancerous, benign, or non cancerous. This kind of procedure helps the doctor to determine what type of cancer the patient suffers from.

The treatment for Gastrointestinal Stromal Tumor depends on the size and location of the tumor, or if it is or not cancerous and if it has widely spread, also on the patient’s overall medical status. There are cases which require a whole team of doctors to determine the best treatment for the patient. The treatment option for this kind of disease can consist in surgery, radiation therapies and chemotherapy. The main goal of the surgical approach is to entirely remove the tumor and the surrounding affected tissue. There are cases in which the tumor has spread too much and has affected the other organs. Usually, doctors administrate a drug called imatinib before the surgical procedure. The operation consists in removing the whole tumor to prevent the recurring. There are cases in which the doctor can remove the surrounding organs, depending on the gravity and location of the tumor. Usually, doctors do not remove the nearby lymph nodes because the Gastrointestinal Stromal Tumor does not spread to them. The second major treatment option for this kind of condition is the radiation therapy, which uses high energy X - rays or certain particles to kill the cancerous cells. The most common form of the therapy is also known as external beam radiation, which is administered by a machine outside the patient’s body. Scientists have discovered a more efficient form of the external radiation therapy called intensity modulated radiation therapy, which reduces the number of killed healthy cells and causes fewer side effects. When the therapy uses implants, it is called internal radiation therapy or brachytherapy. Another way to treat Gastrointestinal Stromal Tumor is using chemotherapy, which is based on certain drugs to kill the cancer cells. There many ways to administrate the drugs: on the oral way, by mouth, intravenously, into a vein, injected either into a muscle, under the skin, or directly into the tumor, and applied on the surface of the patient’s skin.




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