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Gonadotropin Deficiency

Gonadotropin Deficiency General Information

Gonadotropin Deficiency represents a hormonal disorder, and as well as many other medical conditions of this kind, it can lead to major changes in a patient’s organism. This disease involves the participation of two different hormones that influence the development of the male and female reproductive system. These two hormones are the LH or luteinizing hormone and the FSH or the follicle stimulating hormone and have similar effects by stimulating the secretion of the gonads (testes and ovaries). Both these hormones stimulate the developing of the ovaries in women and the testes in men. FSH and LH are hormones released by the pituitary gland also called the hypophysis. When Gonadotropin Deficiency appears, the fertility of men and women is affected, as well as the menstruation in women. Medical professional describe this medical condition as the absence or decreased functioning of the male and female gonads. This hormonal disorder is more commonly known under other names: hypogonadotropic hypogonadism, secondary hypogonadism, or Kallmann syndrome. This type of deficiency is considered a rare inherited medical condition that appears in the puberty age of the patient and affects the development of secondary sexual characteristics that form in this period. It can be inherited through autosomal recessive, X- linked or dominant transmissions. Scientists say that over two thirds of all cases are sporadic. More than 200,000 people only from the United States of America are affected. People who also suffer from hemochromatosis, large pituitary tumors or endocrine deficiency are at high risk of developing this serious hormonal deficiency.

Gonadotropin Deficiency Symptoms

There are three major causes that can lead to the development of this medical condition. The first one consists in a decreased secretion of hypothalamic hormones that generally stimulate the pituitary function. There are cases in which the cause of the small levels of hypothalamic hormones can be congenital. However, they can also be developed in the case of a patient who already suffers from other conditions such as tumor, inflammation, infection, mass lesions or blood supply interruption. A second major cause of the Gonadotropin Deficiency is any event or mass which interrupts the supplying with hormones (especially those produced by the hypothalamus). These events can include tumors and aneurysms. The third major cause of the condition is the affection of the pituitary gland cells. The most common condition that affects these gland cells is the pituitary adenoma, but the cells can be also affected by many other tumors and diseases. The signs and symptoms of the Gonadotropin Deficiency can vary depending on the affected hormones and the severity of the deficiency. In most cases, patients experience the signs and symptoms but do nothing about them until they suffer from another major disease or stress. The most common signs and symptoms of the Gonadotropin Deficiency can include fatigue, sensitivity to cold, weakness, decreased appetite, weight loss and abdominal pain. There are some cases in which the condition can cause low pressure, headaches and visual disturbances. It is very important to treat this condition in due time, especially in the first stages, to prevent the appearance of any future complications and to increase the curing rate.

Gonadotropin Deficiency Treatment

Gonadotropin Deficiency is a very serious hormonal disorder that can have major repercussions on a person’s life. It can be challenging for a health care provider to diagnose this disorder in time because it is hard to differentiate it from another condition, delayed puberty. This is why an exact diagnosis can not be put in most cases until the patient is 18. Only some certain clinical clues and follow up over a certain period of time can help the doctors clarifying upon the right diagnosis. For example, it would be very useful for any medical professional to know the details of the patient’s family medical history. Gonadotropin Deficiency is suggested if there were any anterior cases in the individual’s family, if the relatives suffered from delayed puberty, associated congenital abnormalities, early development of the testes or breasts or anosmia. After the diagnosis is established, the health care provider may proceed with the appropriate therapy. But what treatment option best fits with a patient’s demands and needs depends on several factors, for example, on the patient desire to achieve one or more of the following: bone and muscle mass, secondary sex characteristics or fertility. Several drug categories are prescribed in order to treat Gonadotropin Deficiency. The main categories of drugs that are prescribed by some medical professional are: gonadotropins, hormones, gonadotropin-releasing hormones and oral contraceptives. The hormones are used as a replacement therapy in hypogonadism that may be associated or not with the absence or deficiency of endogenous testosterone. Testosterone may be prescribed as: AndroGel, Andro-LA, Androderm, or Delatest. The main aim of any treatment based on these types of drugs is to maintain trough level in the normal or low range. This type of therapy has a low cost, is effective and safe. We can not precise an exact dosage because this depends on the monitoring of the levels prior to the next injection. The oral contraceptives may as well be used as agents in a hormone replacement therapy. The gonadotropins are stimulating factors for the production of gonadal steroid hormones. The dosage of these drugs when dealing with Gonadotropin Deficiency depends on the levels of testosterone and on the clinical responses. The typical dosage involves a weekly dosing regimen of 500-2500 units, taken in twice a week. The main drug of choice from this category is the human chorionic gonadotropin, prescribed as Corex and has a major role in restoring the spermatogenesis, in normalization of the levels of testosterone and stimulation of testicular growing. It has proven to have fewer effects in males who attempt fertility. Another effective therapy is based on gonadotropin-releasing hormones. Some studies showed that this treatment is a successful in those individuals who are refractory to gonadotropin therapies. We must also precise that treatments against Gonadotropin Deficiency are different in males than in females. In males, the age, the patient’s desire for fertility or the adverse effects of a certain therapy should be considered before deciding which therapy to use. This is highly important because the hormonal equilibrium is extremely important.



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