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Neutropenia

Neutropenia General Information

The majority of people having Neutropenia are born with this blood disorder or may produce it after a viral infection. It may also occur after an exposure to poisonings or as an adverse effect at certain drugs. This disease affects anyone, especially those people who are on a treatment for cancer with chemotherapy. Sometimes, but much more rarely, it appears without a known reason. When we describe Neutropenia we must mention the low number of neutrophils (the blood’s white cells). These blood components minimize the risk of getting infected, being the primary defense arm against foreign injurious organisms that may get inside our body. These cells fight against bacterial infections, surrounding and destroying the bacterium, so that they have a very important role in defending the body. This is why if a person has not got enough red cells he or she is more predisposed to infections of any kind. If you have a disorder of such kind it means that you will get infected very often and extremely easily. Depending on the duration of the disease, we can characterize it as chronic or acute. In both cases a promptly medical intervention is necessary because the patients are susceptible to any kind of infections with bacterium. If the symptoms last more than two to five months, this illness becomes chronic. The infections usually appear in the mouth, lung, skin, sinuses and throat and they may often be life-threatening. It requires hospitalization, both in adults or a children and it is diagnosed after some examinations, including blood tests.

Neutropenia Symptoms

Usually, Neutropenia cannot be detected very easy and the patient remains without a clear diagnostic. The discovery of this disorder usually occurs after sepsis or other severe infections are developed. In the cases of viral infections, Neutropenia symptoms can be really mild. Sadly, the common infections can turn in something unexpected and more serious. For example, we can notice some formation of pus, requiring circulating neutrophil granulocytes that can be notably absent. This relatively common disease appears in persons who are healthy and normal, in Yemenite Jews and in those with dark-skin. The categorization of the causes is a result of a the decreasing quantity of white cells from the blood, pooling of white blood cells (the white blood cells that are out of circulation and are accumulated) or the destruction of them after they are produced.  The symptoms appear after some clear causes such as chemotherapy or aplastic anemia (increased destructions), hemodialysis (sequestration and marginalization) and a very low production in the bone marrow (cancer, certain medications, folate or Vitamin B12 deficiency, radiation or hereditary disorders). The very frequent symptoms of Neutropenia are sore throat, fever, mouth ulcers, shaking chills, diarrhea, a swelling, pain or unusual redness around a wound, burning sensation when urinating and shortness of breathe. The lymphocytes are often destroyed by an extreme vitamin deficiency, some blood diseases, drug toxicity, tuberculosis, and typhoid or virus diseases. Also, the drugs that stimulate the immune system to attack the cells or the antibodies that attack the cells may cause massive white blood cells destruction.

Neutropenia Treatment

As so many other treatments, the one for Neutropenia also depends mainly on the severity and on what caused the disease. The process of diagnosing and treating is long and very confusing for the patient and for the family. The evaluation of the patient its self may demand a lot of time and patience. Each person has another experience and the disease acts differently. So that any doubt, incertitude or question can be addressed to a physician. In general, more than one investigation is needed to establish the right diagnosis in order to proceed as fast as possible with a therapy and avoid any complications. For guidance on management hematology consultations may be necessary. On a full blood count can be detected low neutrophil counts. In some cases this analysis is not enough because the diagnosis may still be uncertain. Then, or if other serious causes are suspected the next step is a bone marrow biopsy and aspiration. In prolonged neutropenic fever or in severe infections that do not respond to the respective treatment, the right thing to do is an infectious disease consultation. The health care providers will remove any harmful agents or drugs and will administrate some stool softeners for a possible constipation. It is also very important to prevent infections of the teeth or mucosa with the adequate oral hygiene. The skin must be treated carefully to avoid any abrasions or wounds. The diet during a severe Neutropenia must be followed with strictness because the patient should eliminate any risks of possible infection. The sources of infection may be the same that cause allergies in the every-day life, for examples flowers, fresh vegetables and fruits.

An ideal therapy for this disease is not yet discovered. All the doctors have are some effective alternative treatments. Patients with autosomal recessive Kostmann's syndrome, severe congenital Neutropenia, myelokathexis and cyclic Neutropenia (in few words, with congenital form) may be helped using recombinant G-CSF (granulocyte-colony stimulating factor) that can have some very effective and fast visible answers. Neutropenia can also be caused by other diseases, such as leukemia, other cancers or tuberculosis, the treatment being simpler, consisting in drugs or therapies for the underlying disease. In comparison with other kind of cancers, this one cannot be treated with a transplantation of stem cells or bone morrow. But what can be treated are some certain causes leading to it (leukemia or aplastic anemia). Patients suffering of severe forms of this disease do not have enough means to fight against the organisms invading their bodies so they can succumb very fast to infection. Immediately hospitalization and powerful antibiotics are given even if the exact location of the infection is not known as soon as the patient has developed the infection. An extremely important factor that shows the gravity of the situation, the existence of an infection in the body and that an urgent medical care is needed is the fever. When this disease is accompanied by a viral infection, it is a sign that will disappear once the infection is gone.




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