BIRON (Buspirone hydrochloride)

Biron Information

Biron is an azaspirondecandione, a non-benzodiazepine anxiolytic. Its mechanism of action is very complex and, so far, it is not totally elucidated. Several different neuropharmacologic processes can be involved. BIRON has an affinity for 5-HT1A -receptors, moderate affinity for DA2-receptors, and weak affinity for 5-HT2-receptors but no affinity for the benzodiazepine receptor complex in vitro. Buspirone selectively blocks presynaptic dopamine receptors. Buspirone increases the firing rate of midbrain dopaminergic nerves. In the locus ceruleus buspirone increases the spontaneous firing of noradrenergic nerves. Biron is one of the many anxiolytics. Its advantages compared to benzodiazepines are that Biron is less sedative, tolerance and abuse are not problems with buspirone and buspirone does not produce withdrawal symptoms like benzodiazepines do. Biron is indicated for anxiety disorders and short term relief of the symptoms of anxiety.

Biron Warnings

Dose adjustments are needed when treating patients with severe renal or hepatic disorders. Biron does not usually impair psychomotor and cognitive function, but some patients may experience sedation. It does not prevent possible symptoms of withdrawal after abrupt cessation of benzodiazepine use. Buspirone may potentiate the effects of alcohol or other CNS depressants. Although Buspirone has only minimal sedative effect, patients should be cautioned about driving a vehicle or operating machinery until it is reasonably certain that Buspirone does not affect these functions adversely.

Use During Pregnancy and Breast-Feeding: Use during pregnancy and breast-feeding is not recommended. Although in animal studies there is no likelihood of foetal damage, adequate human studies are not available. No problems with human breast-fed infants have been reported.

Drug Interactions : Biron is highly bound to serum proteins and may displace other medicines. Data from the controlled clinical trials with over 700 patients suggests safe co-administration of buspirone and analgesics, antihistamines, sedative-hypnotics, contraceptives, and antihypertensives. Diazepam, but not clorazepate, together with buspirone resulted in increased sedation. Potent CYP enzyme inducers may decrease the bioavailability of buspirone. Rifampicin has decreased Buspirone bioavailability to 10% from control values.

Biron is contraindicated in: Patients with hypersensitivity to Buspirone. Myasthenia gravis. Acute narrow-angle glaucoma. Severe liver and kidney dysfunction. Pregnancy and breast-feeding.

Biron Side effects

The various areas and types of side effects are given- Cardiovascular: Non-specific chest pain. Central Nervous System: Dream disturbances EENT: Tinnitus, sore throat, nasal congestion Musculoskeletal: Muscle cramps, muscle spasms, stiff muscles, arthralgias. Neurological: Involuntary movements, slowed reaction time. Respiratory: Hyperventilation, shortness of breath. Sexual Function: Decreased or increased libido. Skin: Oedema, pruritis, flushing, easy bruising, hair loss, dry skin. Sexual Function: Delayed ejaculation, impotence. Skin: acne, thinning of nails.

Biron Overdose

There is no specific antidote for Biron. Treatment of Buspirone overdose consists of symptomatic and supportive measures, immediate gastric lavage, monitoring of respiration, pulse and blood pressure.

Biron Usage guidelines

For anuric patients higher concentrations of the 1-PP metabolite are attained while they are undergoing haemo-dialysis. Hence the dosage of Biron should be reduced by 25-50% in anuric patients. Effect of Food: Plasma Buspirone levels may be roughly three times greater when the tablets are taken with food as compared to administration without food. Adults: Initial dose is 15mg daily (5mg three times a day). The dose may then be increased 5mg per day, as needed, at intervals of 2 to 3 days. The daily dose should not exceed 60mg. Usually if patients do not respond at a total daily dose of 40mg it is unlikely that increasing the dose will be of any benefit. Biron is not recommended for children under 18 years of age. Protect from light and moisture. Store below 30°C. Keep out of reach of children

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