Desferrioxamine

Desferrioxamine Information

Desferrioxamine is a medicine that binds to excess iron in the body. It is then excreted in the urine and faeces, thereby reducing iron levels in the body. Iron overload can also occur as the result of iron overdosage (iron poisoning). Desferrioxamine is given in this situation as an emergency transfusion. Desferrioxamine can also be used to bind to and remove aluminium. It is used in people on dialysis for end-stage kidney failure, with aluminium overload and aluminium-related bone disease.

Desferrioxamine Warning

Regular ear and eye examinations (every 3 months) are essential for people on long-term treatment. Children's growth and body weight should be monitored every 3 months during treatment with this medicine. People with iron overload are particularly susceptible to infection, and desferrioxamine may promote certain infections. If you develop a fever with sore throat (Pharyngitis), abdominal pain or inflammation of the intestines (enteritis/enterocolitis), consult your doctor. Desferrioxamine treatment should be stopped temporarily and antibiotics given. Avoid driving or operating machinary if you experience dizziness, visual disturbances or hearing disturbances during treatment with this medicine. Use with caution in Aluminium related disease of the brain (encephalopathy), Decreased kidney function. Not to be used in Known sensitivity or allergy to any ingredient this medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. This medicine is not recommended for use in pregnancy, particularly in the first trimester, unless considered essential by your doctor. Seek medical advice from your doctor. It is not known if this medicine passes into breast milk. It is not recommended for use during breastfeeding unless considered essential by your doctor. Seek medical advice from your doctor.

Desferrioxamine Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. Headache, Abdominal pain, Blood disorders, Visual disturbances, Decreased kidney function, fever (pyrexia), Disorder of the peripheral nerves causing weakness and numbness (peripheral neuropathy), hearing distubances, dizziness, nausea and vomiting, an extreme allergic reaction (anaphylaxis), itchy rash (urticaria), supression of growth in children and adolescents, pain, swelling, redness and hardening of the skin at the injection site. The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

Desferrioxamine Overdose

High doses of vitamin C (more than 500mg daily) when taken with desferrioxamine, may cause heart disorders. Heart monitoring is recommended if this combination is used. Vitamin C should only be given to people receiving desferrioxamine regularly, and should not be given during the first month of treatment or to people with heart failure. Desferrioxamine should not be given to people taking prochlorperazine, as this may result in prolonged unconsciousness.

Desferrioxamine usage guidelines

The dose of deferoxamine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of deferoxamine. If your dose is different, do not change it unless your doctor tells you to do so. Adults and children over 3 years of age. Dose is based on body weight and must be determined by your doctor. Children up to 3 years of age. The usual dose is 15 mg per kg (7 mg per pound) of body weight per hour, injected into a vein. For chronic iron toxicity: Adults and children over 3 years of age. The usual dose is 500 mg to 1 gram a day, injected into a muscle. Keep out of the reach of children. Store away from heat and direct light. Store the mixed medicine at room temperature for no longer than recommended by your doctor or the manufacturer. Do not refrigerate.

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