CHLORSIG (chloramphenicol)

CHLORSIG Information

CHLORSIG is a broad spectrum antibiotic originally isolated from Streptomyces venezuelae. It is primarily bacteriostatic and acts by inhibition of protein synthesis by interfering with the transfer of activated amino acids from soluble RNA to ribosomes. It is indicted for the treatment of bacterial conjunctivitis and other superficial ocular infections caused by chloramphenicol-sensitive organisms.

CHLORSIG Warnings

Bone marrow hypoplasia, including aplastic anaemia and death, has been rarely reported following local application of chloramphenicol. Chloramphenicol should not be used when less potentially dangerous agents would be expected to provide effective treatment. Ophthalmic agents may retard corneal wound healing. The use of this antibiotic, as with other antibiotics, may result in the overgrowth of non-susceptible organisms, including fungi. If infections caused by non-susceptible organisms appear during therapy, its use should be discontinued and appropriate measures should be taken. In all serious infections, the topical use of chloramphenicol should be supplemented by appropriate systemic medication. Chloramphenicol treatment should, therefore, be avoided during the last week before parturition and during breast feeding. Chloramphenicol is contraindicated in individuals with a history of hypersensitivity to any excipients and/or toxic reaction to the medicine.

CHLORSIG Side Effects

Blood dyscrasias have been reported in association with the use of chloramphenicol (see Warnings and Precautions). Chloramphenicol is absorbed systemically from the eye, and toxicity has been reported following chronic exposure. Dose related toxicity following a single ocular exposure is unlikely. Local irritation with the ophthalmic form may include subjective symptoms of itching or burning. More serious side effects such as angioneurotic oedema; anaphylaxis, urticaria, fever, vesicular and maculopapular dermatitis have been reported in patients sensitive to chloramphenicol and are causes for discontinuing the medication. Similar sensitivity reactions to other materials in topical preparations also may occur.

CHLORSIG Overdose

Accidental ingestion of the medicine is unlikely to cause any toxicity due to low content of antibiotic. CHLORSIG EYE DROPS contains 18.80mg/ml of borax/boric acid as buffer with less than 0.13mg/ml of sodium hydroxide. If the eye drops are accidentally ingested by infants or young children, Poisons Information Centre should be contacted. The medication should be kept out of reach of children. If irritation, pain, swelling, lacrimation or photophobia occurs after undesired eye contact, the exposed eye(s) should be irrigated with copious amounts of room temperature water for at least 15 minutes. If symptoms persist after 15 minutes of irrigation, an ophthalmological examination should be considered.

CHLORSIG Usage guidelines

CHLORSIG EYE DROPS: Instill 1 or 2 drops in the affected eye(s) every two to six hours for two to three days. The interval between applications may then be increased. Discard solution within one month of opening container. Store between 2-8°C. Refrigerate. Do not freeze. After dispensing, store below 25°C. Discard one month after opening. Protect from light. CHLORSIG EYE OINTMENT: Apply 1.5cm every three hours. If ointment is used together with drops for day and night coverage, 1.5cm should be applied before retiring, while using the drops during the day. Store below 25°C

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