CLOROTIR (Cefaclor monohydrate)

Clorotir Information

Clorotir is indicated in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: Otitis media, Lower respiratory infections and Upper respiratory infections. Cefaclor is generally effective in the eradication of streptococci from the nasopharynx; however, substantial data establishing the efficacy of cefaclor in the subsequent prevention of rheumatic fever or bacterial endocarditis are not available at present.

Clorotir Warnings

Careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cefaclor, cephalosporins, penicillins, or other medicines. This product should not be given to those known to be allergic to penicillin or to cephalosporins especially if they have experienced an allergic or urticarial reaction. If an allergic reaction to cefaclor occurs, the medicine should be discontinued and, if necessary, the patient should be treated with appropriate agents, eg. pressor amines, antihistamines, or corticosteroids. Antibiotics, including cefaclor, should be administered cautiously to any patient who has demonstrated some form of allergy, particularly to medicines. Pseudomembranous colitis has been reported with virtually all broad-spectrum antibiotics (including macrolides, semisynthetic penicillins, and cephalosporins); therefore, it is important to consider its diagnosis in patients who develop diarrhoea in association with the use of antibiotics. Such colitis may range in severity from mild to life threatening. Mild cases of Pseudomembranous colitis usually respond to medicine discontinuance alone. In moderate to severe cases, appropriate measures should be taken. Clorotir is contraindicated in patients with known allergy to the cephalosporin group of antibiotics. Prolonged use of cefaclor may result in the overgrowth of nonsusceptible organisms. Careful observation of the patient is essential. If super infection occurs during therapy, appropriate measures should be taken. Clorotir should be administered with caution in the presence of markedly impaired renal function.

Antibiotics, including cephalosporins, should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. There are no adequate and well-controlled studies in pregnant women. This medicine should be used during pregnancy only if clearly needed. The effect on nursing infants is not known. Caution should be exercised when Clorotir is administered to nursing woman.

Interactions with other medicaments and other forms of interaction Patients receiving cefaclor may show a false-positive reaction for glucose in the urine may occur with Benedict's or Fehling's solution or with Clinitest tablets but not with Tes-Tape (Glucose Enzymatic Test Strip, USP, Lilly). There have been rare reports of increased anticoagulant effect when cefaclor and oral anticoagulants were administered concomitantly.

Clorotir Side effects

Nausea and vomiting have been reported rarely. Angioedema has been reported rarely. Cases of serum-sickness-like reactions have been reported with the use of cefaclor. These are characterized by findings of erythema multiforme, rashes, and other skin manifestations accompanied by arthritis/arthralgia, with or without fever, and differ from classic serum sickness in that there is infrequently associated lymphadenopathy and proteinuria, no circulating immune complexes, and no evidence to date of sequelae of the reaction. More severe hypersensitivity reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, and anaphylaxis have been reported rarely. Anaphylaxis may be more common in patients with a history of penicillin allergy.

Clorotir Overdosage

The toxic symptoms following an overdose of Clorotir may include nausea, vomiting, epigastric distress, and diarrhea. The severity of the epigastric distress and the diarrhea are dose related. Protect the patient's airway and support ventilation and perfusion. Meticulously monitor and maintain, within acceptable limits, the patients vital signs, blood gases, serum electrolytes, etc.

Clorotir Usage guidelines

Clorotir is administered orally. The usual adult dosage is 250 mg every 8 to 12 hours. The usual recommended daily dosage for children with mild to moderate infections is 20mg/kg/day in divided doses every 8 to 12 hours. For bronchitis and Pneumonia, the dosage is 20mg/kg/day in divided doses administered 3 times daily. Store below 30°C and protect from moisture. Medicines should be kept out of the reach of children.

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