CONTHRAM

CONTHRAM Information

The use of CONTHRAM Suspension and CONTHRAM FORTE Suspension is strictly limited for the prevention or treatment of constipation in the terminally ill.

CONTHRAM Warnings

CONTHRAM Suspension and CONTHRAM FORTE Suspension may cause staining of the buttocks in incontinent and/or bedridden patients, and in babies or children wearing napkins. This may lead to superficial sloughing of the skin and should be used with caution in all incontinent patients, and is not recommended for the treatment of infants and children in nappies. Oral administration of dantron has been reported to cause liver or intestinal tumors in rats and mice. It has also been reported to be hepato-carcinogenic in rats as well as in mice. There is no sound evidence to conclude a no-effect dose and therefore there may be a risk of such effect in humans. The use of co-danthramer preparations should be restricted to the licensed indications. There is inadequate evidence of safety of the medicine in pregnancy but it has been in wide use for many years without apparent ill consequence. There is no evidence that dantron or poloxamer react with other medicaments or interfere with their action. Dantron may be secreted in breast milk but will not usually be in sufficient amounts to affect the infant.

Contraindications: CONTHRAM Suspension and CONTHRAM FORTE Suspension should not be given when acute or painful conditions of the abdomen are present, or when the cause of constipation is suspected to be intestinal inflammation or obstruction.

CONTHRAM Side Effects

Dantron may cause temporary harmless pink or red colouring of the urine and perianal skin. Prolonged high dosage of co-danthramer suspensions may result in the mucosa of the large intestine becoming coloured. Long term use may result in electrolyte disturbances and in atony and dilation of the colon.

CONTHRAM Overdose

Patients should be given plenty of fluids. An anti cholinergic preparation such as Atropine methonitrate may be given to offset the excessive intestinal motility.

CONTHRAM Usage guidelines

CONTHRAM SUSPENSION: Opioid Induced Constipation: Elderly and Adults: 10-20mL once or twice daily may be required. Children: 2.5-5mL as required. CONTHRAM FORTE SUSPENSION: Opioid Induced onstipation:Elderly and Adults: 5-20mL once or twice daily may be required. Not recommended for children under 12 years. Store below 30 degrees C. Protect from light. Shake well before use.

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