CLOZARIL

Clozaril Information

Clozaril, based on the main ingredient Clozapine, is a tricyclic dibenzodiazepine derivative, part of the atypical antipsychotics class of medication. This drug is available under the form of 25 and 100 mg tablets, which also contain the inactive ingredients povidone, magnesium stearate, lactose, colloidal silicon dioxide, starch and talc.

Clozaril Indications

Clozaril is mainly prescribed for the treatment of patients suffering from treatment-resistant forms of schizophrenia, and may also be employed in the treatment of patients with suicidal tendencies. Clozaril has a strong positive effect on both types of schizophrenic symptoms, positive (hallucinations, delusions) and negative (social and emotional withdrawal) while not presenting any dyscognitive effect. Health care professionals may choose to prescribe Clozaril for the treatment of other medical conditions apart from those listed here. In such cases, it is best to consult your personal physician regarding the reasons for his or her decision.

Clozaril Warnings

Clozaril should not be administered to patients that are suffering from such medical affections as myeloproliferative disease, uncontrolled epilepsy or agranulocytosis, if the patient has received prior Clozapine treatment. Patients with preexisting liver or cardiovascular damage may not be able to start a treatment course with this medicine, or may require dosage adjustments. Other medical conditions may influence the patient’s therapy options as well; as such, it is strongly suggested that the prescribing health care professional is fully aware of the patient’s medical history and general health condition before prescribing a treatment course with Clozaril.

Clozaril Intake Guidelines

The exact medication plan for a patient undergoing therapy with Clozaril will be determined by the examining health care professional. The treatment typically consists of one or two daily intakes of the recommended doses, but may change during the course of the therapy. In some cases, the health care provider may give you different indications on how to take your Clozaril doses. It is best that you closely follow your doctor’s directions. Treatment with this medicine should not be discontinued without your personal physician’s consent.

Clozaril Dosage

In general, Clozaril therapy begins with a low initial dose (in most cases 12.5 mg of the medicine, one half of a normal 25 mg tablet) administered to the patient once or twice per day. As the treatment course continues, the dose is gradually increased by 25 or 50 mg per day. Under normal circumstances the dosage reaches 300 to 450 mg per day within two weeks from the start of the therapy. This medication plan allows the supervising health care professional to determine the organism’s reaction to the drug and minimize the risk of side effects, allowing for prompt action to be taken if any unwanted symptoms appear. Further increases in the daily dosage are possible, however these should not be made more than once or twice per week and the dose should not be increased by more than 100 mg.

Your prescribing health care specialist will determine the appropriate Clozaril dosage in each case, based on a number of case-specific factors. As such, the above information may not apply in all situations. It is strongly recommended that you employ the Clozaril dosage that has been prescribed to you most recently in order to obtain the best effects from the medication therapy.

Clozaril Overdose

It is strongly suggested that you take Clozaril exactly as recommended by the prescribing health care specialist in order to avoid an overdose with this drug. Patients that have ingested larger quantities of the medicine may experience severe signs and symptoms, such as cardiac arrhythmia, aspiration pneumonia, hypersalivation, respiratory failure, tachycardia, hypotension, loss of consciousness, drowsiness or seizure. Coma and death may occur in severe situations. It is extremely important to immediately consult with your personal physician or call the regional or local poisons center if you suspect an overdose with Clozaril. If possible, you should move to the nearest emergency room in order to receive prompt medical attention.

Clozaril Missed Dose

In case you have missed an intake of Clozaril, it is strongly recommended to take it as soon as you remember, unless another dose of the medication is almost due. In such situations it is best to completely skip the missed dose and continue with your normal medication schedule. It is also advised to contact your personal health care professional and consult him or her regarding any further actions that need to be taken in order to correct the situation.

Clozaril Side Effects

Clozaril therapy may cause side effects in some patients; these may be mild to severe and may include neutropenia, agranulocytosis, dizziness, drowsiness, constipation, tachycardia, increased salivation, headache, vision disturbances or rapid weight gain. Some patients have reported experiencing postural hypotension, tremor, rigidity or twitching of the tongue, face, neck, hands or legs. Seizures, hyperglycemia, dysphagia, myocarditis, respiratory depression or liver disorders are also possible. Other side effects that are not listed here are also possible. It is strongly advised to consult your personal physician as soon as you experience any unexpected symptoms during your therapy with Clozaril.

Clozaril Drug Reactions

Clozaril may interact with a number of other drugs and medication leading to the apparition of side effects or causing the medication therapies to yield a different result than expected. You should inform the prescribing health care professional regarding any other medication that you are currently taking before starting a therapy course with Clozaril and also you should consult him or her before starting any new medication therapy while following a treatment course with this drug. Examples of commonly encountered drug reactions are with Carbamazepine, Chloramphenicol, Co-trimoxazole, Phenylbutazone, Penicillamine, sulphonamides, other antipsychotic drugs and with medication employed during chemotherapy. Interaction with other drugs that are not listed here is also possible.

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