Denol

Denol Information

Denol is indicated for Duodenal and gastric ulceration and Non-ulcer Dyspepsia due to H.pylori associated gastritis, when used in conjunction with antibiotic therapy. Denol in combination with tetracycline and metronidazole is indicated for the eradication of H.pylori infection or H. pylori infection associated with non-ulcer Dyspepsia in a 14 day treatment programme.

Denol Warnings

Excessive use of bismuth compounds in the past has occasionally led to reversible encephalopathy. This does not occur with Denol when used as advised. The use of other bismuth containing agents concomitantly is not recommended. There is insufficient information available on the use of Denol during pregnancy and lactation for an assessment of possibly harmful effects although studies in animals have not indicated the presence of any deleterious effects. Drug Interactions : Nothing should be consumed i.e. other medicines, food or drink should be, within half an hour before or after a dose of Denol as they could theoretically interfere with its reaction with the ulcer. The absorption of tetracycline may be reduced if this is given concomitantly with Denol.In severe renal impairment, Denol should be avoided.

Denol Side Effects

Blackening of the stool can occur due to the formation of bismuth sulphide but this can be easily distinguished from melaena. Other effects are mainly gastrointestinal in nature and include nausea, vomiting, constipation and diarrhoea. A few cases of mild allergic reaction have been reported.

Denol Overdose

Symptoms Acute, massive overdose may lead to reversible renal failure with a delayed onset of up to ten days. Immediate treatment with gastric lavage and repeated doses of activated charcoal suspension combined with the use of saline laxatives should be given in all such cases. Blood and urine bismuth levels should be monitored as well as renal function. Further treatment is basically symptomatic.

Denol Usage guidelines

Two denol tablets half an hour before breakfast and two tablets half an hour before dinner or at bedtime. The tablets should be taken with some water. Denol can be taken in this way for up to a maximum of 2 months when necessary. This should be followed by a 2 month period free of bismuth-containing preparations before another course of therapy can be given. Denol should be stored at room temperature until the date mentioned on the package.

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